Centre for Brain Research, IISc




The SANSCOG study is an initiative by CBR in collaboration with NIMHANS, Sri Devaraj Urs Medical College, Kolar and other departments of IISc. This study is envisioned as a prospective community based cohort study with long term follow-up over many years for comprehensive evaluation of the risk and protective factors associated with cognitive changes due to normal ageing, Alzheimer’s disease and other related disorders. The Srinivaspura taluk in Kolar district of the state of Karnataka is the site of the study. The study cohort (n=10,000) comprising of cognitively healthy individuals without dementia in the age group of 45 years and above will undergo detailed assessments comprising of clinical, neurocognitive, lifestyle, anthropometric,biochemical, genetic and multi-modal neuroimaging measures at baseline and periodic follow up.


For India, this is a very important study, as dementia including Alzheimer’s disease will be one of the major burdens that will affect the elderly and emerge as a socio- economic challenge. India and China will see the maximum number of new cases of dementia in the next 2-3 decades.


India is unique in terms of genetic susceptibility, diversity in language, education and socio-economic backgrounds, risk factors - diabetes,hypertension, hypercholesterolemia, midlife obesity, smoking and the rapidly changing socio-cultural milieu wherein the joint family system is changing to nuclear families resulting in differential cognitive engagement.


At present, we do not know the burden caused by dementia including its incidence and prevalence. According to longitudinal studies, it is now well-established that the pathogenesis of AD starts several decades earlier than the manifestation of clinical features.


The SANSCOG study will help to identify the risk and protective factors that contribute to pathogenesis and progression of dementia. We hope that this study, which is one of the largest prospective study for dementia in India with very deep phenotyping will throw light on these unanswered questions.