Dr. S N Suresh
Research Interest: Understanding mechanisms of organellostasis of neurons in health and in disease.
Neurodegenerative diseases such as Alzheimer’s are age-related, debilitating and life-threatening disorders with no disease modifying therapies. Understanding underlying mechanisms at the cellular and sub-cellular levels is essential to decipher the progression of disease pathogenesis. The broad interest of our lab is to understand how neuronal organellostasis is affected in a diseased state. Attaining and maintaining the organellostasis is very crucial for neuronal and organismal homeostasis as it hosts the battery of essential biochemical pathways. Overall, our laboratory is interested in understanding how organellostasis gets perturbed during the pathogenesis of neurodegeneration. State-of-the-art microscopic techniques, biochemical and molecular biology tools will be used to address these questions.
She is interested in elucidating the mechanisms that are regulating the membrane contact sites in health and disease.
- Suresh SN, Chavalmane AK, D J V, Yarreiphang H, Rai S, Paul A, Clement JP, Alladi PA, Manjithaya R. A novel autophagy modulator 6-Bio ameliorates SNCA/?-synuclein toxicity. Autophagy. 2017 Jul 3;13(7):1221-1234.
- Suresh SN, Aravinda K. Chavalmane, Malini Pillai, Veena A, Vidyadhara DJ, Haorei Yarreiphang, Shashank Rai, Abhik Paul, James P Clement, Phalguni Anand Alladi and Ravi Manjithaya. Estrogen related receptor alpha negatively regulates autophagy and its inverse agonist is neuroprotective. Frontiers in molecular neuroscience. 2018, 11: 109.
- Rajasekhar K, Suresh SN, Manjithaya R, Govindaraju T. Rationally designed peptidomimetic modulators of a? toxicity in Alzheimer’s disease. Sci Rep. 2015 Jan 30;5:8139.
- Kolla Rajasekhar, Nagarjun Narayanaswamy, Piyush Mishra, Suresh SN, Manjithaya R. and T. Govindaraju. Synthesis of Hybrid Cyclic Peptoids and Identification of Autophagy Enhancer. ChemPlusChem (2014),79, 25.
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Centre for Brain Research
Indian Institute of Science (IISc)
Malleswaram 18th Cross
Telephone: Office +91 80 2293 3639