Centre for Brain Research, IISc


Vivek Tiwari's Lab


Vivek Tiwari

Vivek Tiwari, PhD
Assistant Professor at the Centre for Brain Research


Dr. Vivek Tiwari obtained his masters in Biochemistry from Department of Biochemistry, University of Hyderabad in the year 2008 and bachelor’s in science (Zoology Hons.) from Banaras Hindu University in the year 2006. He pursued his PhD on understanding neurotransmitter energetic in mouse model of Alzheimer’s disease using Nuclear Magnetic Resonance Spectroscopy at CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India during 2008-2014. Dr. Tiwari was a Postdoctoral fellow in the duration of 2014-2019 at Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. His postdoctoral work involved development and application of MR imaging and in vivo magnetic resonance spectroscopy (MRS) methods to understand human brain functions and metabolic alterations in gliomas.


Major theme of my laboratory at Centre for Brain Research is to employ in vivo Magnetic Resonance Spectroscopy (MRS) and imaging (MRI) for understanding brain metabolism together with genetic and epigenetic studies for patient stratification, improved diagnosis, and monitoring of treatment response in brain diseases, particularly neurodegenerative disorders and glioblastomas. I believe cellular functions are the result of interactions between metabolome, epigenome, genome and neurovascular activities. I believe biochemical reactions in the living system maintain the cellular homeostasis. Diseased cells may reprogram metabolism and that may remodel the epigenome and genome. Targeting and quantifying metabolic changes noninvasively in human brain would be a powerful approach to facilitate diagnosis and evaluate therapeutic responses.
Specifically, my laboratory will focus on molecule tailored in vivo 1H and 13C MRS, resting state and activity based functional-MRI in the human brain together with understanding epigenetic and genetic alterations in tissue biopsies for improved Alzheimer’s and glioblastoma patient management. In vivo metabolic images obtained from spectroscopic imaging, functional measures using cerebral blood flow measurement (perfusion-based imaging) and blood oxygenation level dependent signals (BOLD) together with diffusion weighted imaging will be used to identify the subtle functional and structural changes in healthy and diseased brain.



Present Lab Members

bharateshBharatesh Rayappa S
Bachelors of Engg: Biotechnology from MS Ramaiah Institute of Technology, Bangalore,
Masters of Science: Cognitive Science from Indian Institute of Technology, Gandhinagar, Gujarat
Designation: Project Associate
Research Interest: "Understanding human brain structure and functions with multidisciplinary approach."


    Selected Publications

    1. Tiwari V, Daoud EV, Hatanpaa KJ, Gao A, Zhang S, An Z, Ganji SK, Raisanen JM, Lewis CM, Askari P, Baxter J, Levy M, Dimitrov I, Thomas BP, Pinho MC, Madden CJ, Pan E, Patel TR, DeBerardinis RJ, Sherry DA, Mickey BE, Malloy CR, Maher EA, Choi C. Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. Neuro-Oncology. 2020; (https://doi.org/10.1093/neuonc/noaa034)

    2. Tiwari V, Mashimo T, An Z, Vemireddy V, Piccirillo S, Askari P, Hulsey KM, Zhang S, de Graaf RA, Patel TR, Pan E, Mickey BE, Maher EA, Bachoo RM, Choi C. In vivo MRS measurement of 2‐hydroxyglutarate in patient‐derived IDH‐mutant xenograft mouse models versus glioma patients. Magnetic Resonance in Medicine. 2020; (doi: 10.1002/mrm.28183)

    3. An Z, Tiwari V, Levy M, Hatanpaa K, Pan E, Maher EA, Patel TR, Mickey B, and Choi C. 3D High-Resolution Imaging of 2-Hydroxyglutarate in Glioma Patients using DRAG-EPSI at 3T In Vivo. Magnetic Resonance in Medicine C. 2019; 81(2):795-802

    4. Tiwari V, An Z, Wang Y, Choi C. Distinction of the GABA 2.29 ppm resonance using triple refocusing at 3TIn Vivo. Magnetic Resonance in Medicine. 2018; 80(4):1307-1319.

    5. An Z, Tiwari V, Ganji SK, Baxter J, Levy M, Pinho M, Pan E, Maher EA, Patel TR, Mickey B, and Choi C. Echo-planar spectroscopic imaging with dual-readout alternated gradients (DRAG-EPSI) at 7 T: application for 2-hydroxyglutarate imaging in glioma patients. Magnetic Resonance in Medicine. 2018; 79(4):1851-1861

    6. Tiwari V, An Z, Ganji SK, Baxter J, Mickey B, Pan E, Maher EA, Pinho M and Choi C. Measurement of Glycine in healthy and tumorous brain by triple-refocusing MRS at 3T In Vivo. NMR Biomedicine 2017; 30: e3747

    7. Tiwari V, Saba K, Veeraiah P, Lakhotia SC, and Patel AB. Amalaki Rasayana Improved Memory and Neuronal Metabolic Activity in APP-PS1 Mouse Model of Alzheimer’s Disease AβPP-PS1 Mouse Model of Alzheimer's Disease. J. Biological Sciences. 2017; 42(3):1-9

    8. Tiwari V, Patel AB. Pyruvate Carboxylase and Pentose Phosphate Fluxes are reduced in AβPP-PS1 Mouse Model of Alzheimer's Disease: A 13C NMR Study. J. Alzheimer’s Disease. 2014; 41:2, 387-399

    9. Tiwari V, Susmitha A, Patel AB. Glutamatergic and GABAergic TCA cycle and neurotransmitter cycling fluxes in different regions of mouse brain. J. Cerebral Blood Flow and Metabolism. 2013; 33:1523-1531

    10. Tiwari V, Veeraiah P, Subramaniam V, Patel AB. Differential Effects of Ethanol on Regional Glutamatergic and GABAergic Neurotransmitter Pathways in Mouse Brain. J. Neurochemistry. 2013; 128:628-640

    11. Tiwari V, Patel AB. Impaired Glutamatergic and GABAergic function at Early Age in APPswe-PS1dE9 mice: Implications for Alzheimer’s disease. J. Alzheimer’s Disease. 2012; 28:4, 765769

    12. Google Scholar Link for all publications

      Awards and Honors

      • Suma Cum Laude Merit Award at 27th Annual Meeting and Symposia of International Society for Magnetic Resonance in Medicine at Montreal, Canada May 11-16, 2019

      • UT Southwestern Postdoc Symposia Award for Highest Scored Abstract at the Annual Postdoc Symposia, UT Southwestern Medical Center, Dallas, Sept 21, 2018

      • Magna Cum Laude Merit Award at 25th Annual Meeting and Symposia of International Society for Magnetic Resonance in Medicine at Hawaii, April 21-27, 2017

      • A.R. Gopala Aiyengar Best Poster Award at Annual Meeting of the Indian Biophysical Society, Chennai, January 2012

      • D.M. Bose Best Poster Award at 7th Asian Biophysics Association Symposium & Annual Meeting of the Indian Biophysical Society, New Delhi, February 2011


Centre for Brain Research
SID (Innovation centre) complex
Indian Institute of Science (IISc)
Malleswaram 18th Cross
Karnataka, INDIA.

Email: vivekt[at]iisc.ac.in
Telephone: Office +91 80 2293 3588