Centre for Brain Research, IISc


Major Areas

CBR undertakes interdisciplinary research in basic and clinical neuroscience to understand disorders of the aging brain through advanced genetic, biochemical, neuroimaging and neurocognitive investigations. These studies are dovetailed with research on model systems to identify the molecular underpinnings of age-related brain disorders.


Genome wide association studies (GWAS), whole genome sequencing (WGS), advanced computational approaches and brain imaging investigations are being implemented through large population studies, namely Srinivaspura Aging, Neuro Senescence and COGnition (SANSCOG) study, Tata Longitudinal Study on Aging (TLSA), and GenomeIndia.


Genetic and genomic studies are being performed with advanced techniques to identify common, low frequency, rare, single nucleotide polymorphisms, and structural genetic variations that could contribute to healthy aging and/or neurological disorders.


Brain imaging investigations are being conducted to identify structural, vascular, and metabolic alterations in aging brain using advanced brain imaging methods at 3 Tesla state-of-the-art human MRI scanner.


Researchers at CBR are also investigating the early functional and structural changes at the synapse, dynamics of filamentous actin and its modulators at the dendritic spine, oxidative stress, synaptic dysfunction, sex specific differences using mouse model of Alzheimer’s disease. Extensive studies are being performed to study molecular underpinnings of synaptic dysfunction during transient as well as repeated vasoconstriction in an animal model of vascular dementia. Research groups are engaged in neurobehavioral investigations to delineate the early cognitive and behavioral deficits, and their underlying neural circuit mechanisms.


For more details of the research work, please visit the research groups.